This book constitutes the proceedings of the 26th International Conference on Enterprise Design, Operations, and Computing, EDOC 2022, which took place in Bozen-Bolzano, Italy, in October 2022. The 15 full papers included in this book were carefully reviewed and selected from 48 submissions. They were organized in topical sections as follows: enterprise security; enterprise architecture; business process modeling and monitoring; business process mining and discovery; and process-driven applications.