The aim of this work was to find out the main factors that negatively or positively influenced SARS-CoV-2 immunization in the National Immunization Campaign. The study used the exploratory and descriptive bibliographic research method, analyzing various studies relating to the subject, making a parallel between various authors. The findings address the identification of the main factors that have interfered with immunization, causing the low acceptance of the vaccine against covid-19, causing 699,310 deaths in Brazil up to the date of the research, not only due to the lack of immunization, but also associated with misinformation. This work concludes by drawing the attention of the competent authorities to the rejection of groups with comorbidities, associated with cultural, religious and ideological aspects. A paradox was also made of the narratives of the authors researched to find the main axes of opposition to immunization, associating measures to combat covid-19.