Horizons in World Cardiovascular Research. Volume 19 studies the binding capabilities of cariprazine, clozapine, risperidone, olazapine, quentiapine, ziprazidone, aripirazole, haloperidol, blonanserin, iloperidone, eticlopride, amisulpride and nemonapride. The comprehensive understanding of the molecular-level mechanisms of drug-induced side effects associated with cardiovascular diseases is of paramount importance for the effective management of schizophrenia. Thoracic aortic surgery has undergone major changes in the last two decades, resulting in more favourable short- and long-term outcomes. Better understanding of underlying pathologies, re-definition of guidelines and classifications, and the evolution of diagnostics, intraoperative techniques, postoperative care and post-discharge outpatient follow-up have collectively contributed to this success. The authors summarize the cornerstones of this evolvement. The various features of the different systems and devices for complete closure of the patent foramen ovale tunnel are described, highlighting findings that are useful for interventional cardiologists. Lastly, the inter-core laboratory variability of qualitative comparative analysis parameters is assessed in comparison to the intra-core laboratory variability in a randomized controlled trial evaluating drug-eluting stents.