Condensed Matter Structural Chemistry builds on the foundational establishment of condensed matter chemistry; a new discipline to advance chemical and physical sciences by integrating multi-level structural perspectives into reaction chemistry. This book focuses on the structural chemistry branch, emphasizing the dynamic evolution of condensed matter structures under diverse conditions. It systematically explores multi-level structures-from electronic and crystal phases to defects in solids-and their critical roles in chemical reactions, supported by advanced in situ characterization techniques and emerging AI-driven condensed-matter engineering.Sections highlights interdisciplinary connections with material and life sciences, addressing solids, liquids, and biological condensed phases, and illustrating how structural changes influence reaction pathways and outcomes. Intended for academic researchers, industrial developers, and advanced students in Chemistry, Physics, and Material Science, this book serves as a comprehensive guide to the structural underpinnings of condensed-matter reactions. - Presents a broad perspective on chemistry through the lens of condensed matter chemistry, offering a more realistic approach to studying chemical reactions - Highlights the dynamic evolution of structures and their impact on chemical reactions - Covers a broad range of condensed phases, including solids, liquids, and biological systems with interdisciplinary relevance - Integrates cutting-edge in situ characterization techniques and AI-driven approaches